Dec 01, · Generally 10 mg or less is adequate, but up to 20 mg intravenous may be given, particularly when concomitant narcotics are omitted. If intravenous cannot be used, 5 mg to 10 mg intramuscular approximately 30 minutes prior to the procedure. Muscle Spasm: Associated with local pathology, cerebral palsy, athetosis, stiff-man syndrome or tetanus. Feb 02, · Diazepam is injected into a muscle, or into a vein through an IV. You will receive this injection in a medical or surgical setting. Diazepam injection is for short-term use only. Diazepam injection is usually given as a single dose just before a surgery or medical procedure.
There will be no changes to other Yahoo properties or services, or your Yahoo account. You can find more information about the Yahoo Answers shutdown and how to download your data on this help page. I am having dental work tomorrow and I will be given a 10mg valium 30 minutes before my procedure. I have never taken a valium before and I am wondering how it will make me feel.
I never take any type of pills so I am assuming that I have a low tolerance. Will I be able to stay awake or will it force me to go to sleep? How long will it take for these effects to wear off? I have severe anxiety about taking medications. When I take this will it cause my anxiety to go away? If you are what does sedentary mean usda anxious when you take it, the Valium won't make you go to sleep, but after the procedure you will probably be very groggy.
Effects seem to last different amounts of time for different individuals. Could be a few hours, could be a few days.
Yes it will cause your anxiety to go away. You might not even remember the procedure, or only bits and pieces. I wonder if they give you laughing gas with that too? Wow 10mg, that's awesome! For someone who's never had it, that will be quite a strong dose. I used to be prescribed it for how to inject valium 10mg and was only allowed 5mg tablets. They just make you calm and relaxed and a little tired. Nothing to be stressed about, it will make things a lot easier for you :.
It will make you feel lot drowsy and sleepy. But will take good care of the anxiety caused by vasectomy procedure. It will take your anxiety away and will put you to sleep. It'll take a couple of hours to get back to normal.
Brittany C. Any info would be great. Thanks in advance. Answer Save. Ignacio Judas Christopher. Could be a few hours, could be a few days Yes it will cause your anxiety to go away. Hi, It may make you sleepy or groggy It will take approximately hours to wear off. You will need someone to drive you home. It may help some with your anxiety, may not Hope you surgery goes well, Hope you will feel how to flash zte mf190 modem really soon Glad to help you!!
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I have 10mg valium (generic). I want to convert them into an injectable solution. How do I do that? I did not know if boiling them into a liquid using water is safe to inject with all of the coloring, and glues. Jan 01, · this might be due to the fact that such injections should be given slowly - a regular 2ml (= 10mg) vial of diazepam is supposed to be administered over a time of two minutes (this applies to i.v., can't say exactly about i.m.).. SWICDR doubts, but cannot say exactly whether this is usually done, especially in emergency situations, but at least it's what is recommended. if given more rapid, it is . Intramuscular injection (Diazepam injection solution only): This route is usually not recommended due to slow and erratic absorption. Inject deeply into a large muscle mass.
Medically reviewed by Drugs. Last updated on Oct 1, Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration.
Note: Solution may appear colorless to light yellow. Diazepam is a benzodiazepine derivative chemically designated as 7-chloro-1,3-dihydromethylphenyl-2H-1,4-benzodiazepinone.
It is a colorless crystalline compound, insoluble in water, with the following molecular structure:. In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses.
Diazepam was found to have transient cardiovascular depressor effects in dogs. Long-term experiments in rats revealed no disturbances of endocrine function. Injections into animals have produced localized irritation of tissue surrounding injection sites and some thickening of veins after intravenous use.
Diazepam is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. In acute alcohol withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
As an adjunct prior to endoscopic procedures if apprehension, anxiety or acute stress reactions are present, and to diminish the patient's recall of the procedures. Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology such as inflammation of the muscles or joints, or secondary to trauma ; spasticity caused by upper motor neuron disorders such as cerebral palsy and paraplegia ; athetosis; stiff-man syndrome; and tetanus.
Injectable diazepam is a useful adjunct in status epilepticus and severe recurrent convulsive seizures. Diazepam is a useful premedication the intramuscular route is preferred for relief of anxiety and tension in patients who are to undergo surgical procedures. Intravenously, prior to cardioversion for the relief of anxiety and tension and to diminish the patient's recall of the procedure. Injectable diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.
Concomitant use of benzodiazepines, including diazepam, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of benzodiazepines and opioids for use in patients for whom alternative treatment options are inadequate. Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone.
If a decision is made to prescribe diazepam concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. When used intravenously, the following procedures should be undertaken to reduce the possibility of venous thrombosis, phlebitis, local irritation, swelling, and, rarely, vascular impairment; the solution should be injected slowly, taking at least one minute for each 5 mg 1 mL given; do not use small veins, such as those on the dorsum of the hand or wrist; extreme care should be taken to avoid intra-arterial administration or extravasation.
Do not mix or dilute diazepam with other solutions or drugs in syringe or infusion container. If it is not feasible to administer diazepam directly intravenous, it may be injected slowly through the infusion tubing as close as possible to the vein insertion.
Concomitant use of barbiturates, alcohol or other central nervous system depressants increases depression with increased risk of apnea. Resuscitative equipment including that necessary to support respiration should be readily available. When diazepam is used with a narcotic analgesic, the dosage of the narcotic should be reduced by at least one-third and administered in small increments.
In some cases the use of a narcotic may not be necessary. Diazepam Injection should not be administered to patients in shock, coma, or in acute alcoholic intoxication with depression of vital signs. As is true of most CNS-acting drugs, patients receiving diazepam should be cautioned against engaging in hazardous occupations requiring complete mental alertness, such as operating machinery or driving a motor vehicle.
Tonic status epilepticus has been precipitated in patients treated with intravenous diazepam for petit mal status or petit mal variant status. An increased risk of congenital malformations associated with the use of minor tranquilizers diazepam, meprobamate and chlordiazepoxide during the first trimester of pregnancy has been suggested in several studies.
Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered. Patients should be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physicians about the desirability of discontinuing the drug.
In humans, measurable amounts of diazepam were found in maternal and cord blood, indicating placental transfer of the drug. Until additional information is available, Diazepam Injection is not recommended for obstetrical use. Efficacy and safety of parenteral diazepam has not been established in the neonate 30 days or less of age. Prolonged central nervous system depression has been observed in neonates, apparently due to inability to biotransform diazepam into inactive metabolites. In pediatric use, in order to obtain maximal clinical effect with the minimum amount of drug and thus to reduce the risk of hazardous side effects, such as apnea or prolonged periods of somnolence, it is recommended that the drug be given slowly over a three-minute period in a dosage not to exceed 0.
After an interval of 15 to 30 minutes the initial dosage can be safely repeated. If, however, relief of symptoms is not obtained after a third administration, adjunctive therapy appropriate to the condition being treated is recommended. Benzyl alcohol has been reported to be associated with a fatal gasping syndrome in premature infants. Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after intravenous administration.
The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. The usual precautions in treating patients with impaired hepatic function should be observed. Metabolites of diazepam are excreted by the kidney; to avoid their excess accumulation, caution should be exercised in the administration to patients with compromised kidney function.
Since an increase in cough reflex and laryngospasm may occur with peroral endoscopic procedures, the use of a topical anesthetic agent and the availability of necessary countermeasures are recommended. Propylene glycol toxicity has been reported in patients treated with Diazepam Injection at doses significantly greater than recommended. Propylene glycol toxicity is associated with an anion gap metabolic acidosis, serum hyperosmolality, and increased lactate.
Propylene glycol toxicity can cause acute tubular necrosis which can progress to multi-organ failure , mental status changes, hypotension, seizures, and cardiac arrhythmias. Patients at high risk for propylene glycol toxicity include those with renal dysfunction, hepatic dysfunction, impaired alcohol dehydrogenase enzymes, or other comorbidities such as a history of alcoholism.
The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation. If diazepam is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed—particularly with known compounds which may potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants.
In highly anxious patients with evidence of accompanying depression, particularly those who may have suicidal tendencies, protective measures may be necessary. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol.
The clearance of diazepam and certain other benzodiazepines can be delayed in association with cimetidine administration. The clinical significance of this is unclear. Side effects most commonly reported were drowsiness, fatigue and ataxia; venous thrombosis and phlebitis at the site of injection.
Other adverse reactions less frequently reported include: CNS: confusion, depression, dysarthria, headache, hypoactivity, slurred speech, syncope, tremor, vertigo. Cardiovascular: bradycardia, cardiovascular collapse, hypotension.
EENT: blurred vision, diplopia, nystagmus. Skin: urticaria, skin rash. Other: hiccups, changes in salivation, neutropenia, jaundice.
Paradoxical reactions such as acute hyperexcited states, anxiety, hallucinations, increased muscle spasticity, insomnia, rage, sleep disturbances and stimulation have been reported; should these occur, use of the drug should be discontinued. Minor changes in EEG patterns, usually low-voltage fast activity, have been observed in patients during and after diazepam therapy and are of no known significance. In peroral endoscopic procedures, coughing, depressed respiration, dyspnea, hyperventilation, laryngospasm and pain in throat or chest have been reported.
Because of isolated reports of neutropenia and jaundice, periodic blood counts and liver function tests are advisable during long-term therapy. Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol convulsions, tremor, abdominal and muscle cramps, vomiting and sweating , have occurred following abrupt discontinuance of diazepam.
The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms dysphoria and insomnia have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed.
Addiction-prone individuals such as drug addicts or alcoholics should be under careful surveillance when receiving diazepam or other psychotropic agents because of the predisposition of such patients to habituation and dependence. Dosage should be individualized for maximum beneficial effect. The usual recommended dose in older children and adults ranges from 2 mg to 20 mg intramuscular or intravenous, depending on the indication and its severity. In some conditions, e.
See dosage for specific indications. In acute conditions the injection may be repeated within one hour although an interval of 3 to 4 hours is usually satisfactory. Lower doses usually 2 mg to 5 mg and slow increase in dosage should be used for elderly or debilitated patients and when other sedative drugs are administered.
For dosage in infants above the age of 30 days and children, see the specific indications below. When intravenous use is indicated, facilities for respiratory assistance should be readily available.
The solution should be injected slowly, taking at least one minute for each 5 mg 1 mL given. Do not use small veins, such as those on the dorsum of the hand or wrist. Extreme care should be taken to avoid intra-arterial administration or extravasation. Once the acute symptomatology has been properly controlled with Diazepam Injection, the patient may be placed on oral therapy with diazepam if further treatment is required. NOTE: Solution may appear colorless to light yellow.
Intravenous administration should be made slowly. Moderate Anxiety Disorders and Symptoms of Anxiety. Severe Anxiety Disorders and Symptoms of Anxiety. Acute Alcohol Withdrawal: As an aid in symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
Endoscopic Procedures: Adjunctively, if apprehension, anxiety or acute stress reactions are present prior to endoscopic procedures. Dosage of narcotics should be reduced by at least a third and in some cases may be omitted. See Precautions for peroral procedures.
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